Known for his contagious energy and sometimes unconventional advice, Paul Nurse talks about Brexit and its effects on scientists and research, and why he has heeded the call to leadership in science – the same science that politicians say they're following. He also recalls his early years in biology as a spider hunter and why he thinks it's vital to ponder the big questions like "What is life?" Paul Nurse received the 2001 Nobel Prize in Physiology or Medicine "for discoveries of key regulators of the cell cycle", sharing the distinction with Tim Hunt and Leland Hartwell.

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