Composite Nuclear Grading System to Predict Survival in Epithelioid Peritoneal Mesothelioma

This episode’s guest, Dr. David Chapel, was the recipient of the 2020 USCAP Stephen Vogel Award for his research as a trainee in the University of Chicago! Here, he discusses his recent report on a multi-institutional cohort of 225 malignant peritoneal mesotheliomas, assessed for 21 clinical, morphologic, and immunohistochemical potential prognostic parameters. The exemplary study, published in Modern Pathology, clarifies the complex interaction of clinical and pathologic features in peritoneal mesothelioma and validates the prognostic significance of a standardized nuclear grading system.


Study by Chapel et al, Malignant peritoneal mesothelioma: prognostic significance of clinical and pathologic parameters and validation of a nuclear-grading system in a multi-institutional series of 225 cases. Modern Pathology, 34, 380-395, 2021. https://www.nature.com/articles/s41379-020-00688-4


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